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KMID : 0383819660130020025
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Tuberculosis and Respiratory Diseases
1966 Volume.13 No. 2 p.25 ~ p.28
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COMPARISON OF SINGLE AND THREE DIVIDED DOSAGE OF PAS AND INH COMBINED THERAPY IN ACTIVE PULMONARY TUBERCULOSIS
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이상계(李相桂)/SANG KAY LEE
이종용(李宗鎔)/곽동수(郭東秀)/민백기(閔白基)/임병우(林炳雨)/황빈(黃彬)/JONG YONG LEE/DONG SOO KWAK/BAEK KI MIN/BYONG WOO RHIM/BIN HWANG
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Abstract
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302 patient were randomly selected among the cases of active pulmonary tuberculosis
admitted to the 36th Army Hospital during the period from March 1963 to November
1965.
INH 300㎎ plus PAS 9gm were given daily for six months in two groups, they are:
1) 175 cases of once daily administration.
2) 127 cases of three divided daily administration of above regimens.
The writers followed up Roentgenological changes, bacteriological conversion and
untoward reactions.
The results are summarized as follows
1) Roentgenological study revealed the sum of marked and moderate improvement in
the single does group were 69.2%, and in the t.i.d. group 65.5%.
Slightly improved in 21.1% of the single dose group and 27.6% in the divided does
group.
No changes stayed in similar rate in both group: former 6.3% and latter 6.2%.
In both groups, no significant difference was indicated for the improvement rate seen
totally.
2) The criteria for bacteriological conversion used for this study, were three
consecutive negative smears and cultures, obtained within a period of three months.
Bacteriological conversion rate was 66.2% in the single dose group and 58.1% in the
divided does group.
3) In both groups, there was no significant difference in untoward effects.
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